Antibiotic Resistance: Understanding and Responding to an Emerging Crisis

Product Author Bios

Karl Drlica, Ph.D. is a Principal Investigator at the Public Health Research Institute and Professor of Microbiology & Molecular Genetics at the UMDNJ–New Jersey Medical School in Newark, NJ. His laboratory focuses on fluoroquinolone action and resistance with Mycobacteriun tuberculosis and other bacteria, including approaches for slowing the enrichment and amplification of resistant bacterial subpopulations.

David S. Perlin, Ph.D. is Executive Director of the Public Health Research Institute and UMDNJ Regional Biocontainment Laboratory, as well as Professor of Microbiology & Molecular Genetics at the New Jersey Medical School in Newark, NJ. He is also a Fellow of the New York Academy of Sciences. Dr. Perlin’s laboratory explores mechanisms of antifungal drug resistance, rapid detection of drug resistant bloodstream pathogens in high-risk patients, and the application of small-animal models for the study of respiratory pathogens.

Authored by two leading investigators, this book presents a thorough and authoritative overview of this multifaceted field of science. Pathogenic bacteria have been evolving and spreading resistance to diverse classes of antibiotics. As a result, we risk losing our ability to control and treat infectious diseases. Understanding antibiotic resistance, therefore, is becoming increasingly essential for a broad audience of healthcare professionals, biomedical and public health researchers, students, and policymakers. The authors answer questions such as: What is resistance? How does it emerge? How do common human activities contribute to resistance? What can we do about it? How can we strengthen our “first lines of defense” against resistance? Are there better ways to discover new antibiotics? What unique issues are associated with MRSA and viral influenza? In addition to defining and evaluating one of the most important emerging threats to public health, the authors explain what can be done to minimize risks to public health, and to preserve and extend the effectiveness of existing and new antibiotics.

Table of Contents

Preface     xv

Chapter 1 Introduction to the Resistance Problem     1

Chapter 2 Working with Pathogens     17

Chapter 3 A Survey of Antibiotics     31

Chapter 4 Dosing to Cure     55

Chapter 5 Emergence of Resistance     73

Chapter 6 Movement of Resistance Genes Among Pathogens     91

Chapter 7 Transmission of Resistant Disease     105

Chapter 8 Surveillance     125

Chapter 9 Making New Antibiotics     139

Chapter 10 Restricting Antibiotic Use and Optimizing Dosing     149

Chapter 11 Influenza and Antibiotic Resistance     167

Chapter 12 Avoiding Resistant Pathogens     177

Afterword A Course of Action     203

Appendix A Molecules of Life     207

Appendix B Microbial Life Forms     221

Glossary     227

Literature Cited     233

Index     251