Chips, Clones, and Living Beyond 100: How Far Will the Biosciences Take Us?
- By Paul J. H. Schoemaker, Joyce A. Schoemaker
- Published Sep 8, 2009 by FT Press. Part of the FT Press Science series.
- Copyright 2010
- Dimensions: 6 X 9
- Pages: 240
- Edition: 1st
- Book
- ISBN-10: 0-13-715385-6
- ISBN-13: 978-0-13-715385-5
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Product Author Bios
Paul J. H. Schoemaker, Ph.D. is Research Director of the Mack Center for Technological Innovation at The Wharton School, where he teaches strategy and decision making. Dr. Schoemaker is also the founder and chairman of Decision Strategies International, Inc., a consulting and training firm specializing in strategic planning and executive development. He has written more than 100 academic and applied papers as well as coauthored numerous books, including Decision Traps, Wharton on Managing Emerging Technologies, Winning Decisions, Profiting from Uncertainty, and Peripheral Vision. He serves on multiple boards.
Joyce A. Schoemaker, Ph.D. has conducted basic research in microbiology and molecular genetics at the University of Chicago and taught microbiology at Villanova University. She has held positions in research and management at several biotechnology companies, including Celltech in London, and has published numerous scientific articles in biology. She is coauthor of Healthy Homes, Healthy Kids: Protecting Your Children From Everyday Environmental Hazards. Dr. Schoemaker has a long-standing interest in environmental issues as well as the emerging biosciences.
The key scientific discoveries of the 21st century will emerge from the biosciences. These discoveries will impact our lives in ways we can only now begin to imagine. In this book, two of the field's leading experts help us imagine those impacts. Paul and Joyce A. Schoemaker tour the remarkable field of biosciences as it stands today, and preview the directions and innovations that are most likely to emerge in the coming years. They offer a clear, non-technical overview of crucial current developments that are likely to have enormous impact, and address issues ranging from increased human longevity to global warming, bio-warfare to personalized medicine. Along the way, they illuminate each of the exciting technologies and hot-button issues associated with contemporary biotechnology - including stem cells, cloning, probiotics, DNA microarrays, proteomics, gene therapy, and a whole lot more. The Schoemakers identify emerging economic, political, and technical drivers and obstacles that are likely to powerfully impact the way the biosciences progress. Then, drawing on Paul Schoemaker's unsurpassed experience helping global organizations prepare for the future, the authors sketch multiple long-term scenarios for the biosciences - and reveal how they will impact your health, family, career, society, even the Earth itself.
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33 of 34 people found the following review helpful
Brief, Misleading at Times, and...Brief,
This review is from: Chips, Clones, and Living Beyond 100: How Far Will the Biosciences Take Us? (Hardcover)
Customer review from the Amazon Vine™ Program (What's this?)
I am not sure what the point of this book was intended to be. Perhaps it is intended as a primer to businesspeople to lure them into investing in biosciences research. My second best guess is that this is intended as a means to make investors feel like they understand this technology, so that they can feel comfortable trading in these stocks. These goals seem likeliest, as opposed to, you know, actually TEACHING something, as it is not as accurate as it should be in many respects.For example, easily checked facts were wrong. On page 4, the research of Dr. Cynthia Kenyon on daf-2 (italics!) is mentioned. This was not the first discovery of a longevity gene, or even one in C. elegans (I wish there were italics available in reviews!). To the best of my knowledge, the earliest discovery of such a gene was in 1988, five years earlier, Tom Johnson and his colleagues identified and cloned a gene named age-1, which has many of the same effects as daf-2 (they are, in fact, in the... Read more
8 of 9 people found the following review helpful
I'll take future possibilities with a side order of science, please...,
This review is from: Chips, Clones, and Living Beyond 100: How Far Will the Biosciences Take Us? (Hardcover)
Customer review from the Amazon Vine™ Program (What's this?)
When I ordered this book, I figured I'd be learning about new and emerging technologies that would increase the quality of life for everyone on our little planet.Unfortunately, I should have read the product description a little more carefully - as you'll see below, this book focuses more on future possibilities of the year 2025 and less on the bioscience technologies themselves. I'll pick apart the back cover descriptions to illustrate my dissatisfaction with this book. Let's start from the top: ["A stimulating and exciting look at how we got to the present state of health care and where we can potentially go. A unique perspective and a great read." David Lester, Ph.D., President, ITHW Inc.; formerly Director, Human Health Technologies, Pfizer Inc.] That's the key phrase: where we can _potentially_ go. Several chapters in this novel make projections about the biosciences and how improvements or failures can affect family structures,... Read more
3 of 3 people found the following review helpful
Textbookish, By
This review is from: Chips, Clones, and Living Beyond 100: How Far Will the Biosciences Take Us? (Hardcover)
Customer review from the Amazon Vine™ Program (What's this?)
While chock-full of great information, this book is unfortunately written too much like a textbook for my taste (i.e., it puts me to sleep when I try to read it for too long in a single sitting). From other books of this type I have read, I know this information can be made more palatable for the non-scientist, so I was a bit disappointed that this text - which sounded appealing - wasn't more readable for the lay-person.That said, for those who do want to learn more about the biosciences and the advances currently being made in the field, this is definitely a good place to start. |
Online Sample Chapter
Table of Contents
Foreword xii
Preface xiv
Chapter 1 Living well beyond 100 1
Great progress made, much more to come 1
Medical challenges and promises 4
Living well versus living longer 7
Social challenges and promises 10
Can we afford old age? 11
Government and business 13
The journey ahead 17
Chapter 2 A short history of biomedicine 21
Improving hygiene 21
The power of immunology 23
Monoclonal antibodies 24
The discovery of antibiotics 25
The DNA revolution 26
Recombinant DNA and cloning 27
Biotechnology 29
Unraveling the code 31
Conclusion 33
Chapter 3 Snapshot of the biosciences 35
DNA-based technologies 35
Genomics 37
Genetic testing 37
DNA chips 39
Pharmacogenetics 40
Cloning 41
Gene therapy 43
RNA-based technologies 45
Antisense technology 45
RNA interference (RNAi) 46
Protein-based technologies 46
Vaccines 47
Monoclonal Antibodies 48
Proteomics 49
Cell-based and other technologies 50
Stem cells 50
Antimicrobials 51
Conclusion 52
Chapter 4 Bio-driven convergence 57
Converging technologies 58
Telemedicine 58
Remote diagnostics 59
Biological drug factories 59
Biochips 59
Tissue engineering 60
Imaging 61
Multidirectional synergies 62
Shifting industry boundaries 64
Healthcare and IT 65
Medical information handling 65
Medical data storage 66
Computers and drug discovery 66
Remote monitoring and the wired home 67
Reshaping bioinformatics 67
Bioinformatics and gene banks 69
Personalized medicine 70
Systems biology and holistic medicine 70
Biosensors 72
Nano devices 72
Commercialization challenges 73
Technological challenges: biocompatibility 74
Regulatory challenges: clinical safety and efficacy 74
Political challenges: privacy and ownership 74
Social challenges: consumer advocacy 75
The road ahead 76
Chapter 5 The business of biomedicine 79
The pharmaceutical industry 79
Diminishing drug pipelines 82
The biotechnology sector 85
Medical device industry 89
Cardiovascular device segment 89
Orthopedic device segment 91
Neurological device segment 91
Medical diagnostics industry 92
Laboratory testing 93
Point-of-care (POC) patient monitoring and diagnosis 94
Prevention and disease management 95
Conclusions 97
Chapter 6 Healthcare under stress 101
Stress in developed nations 103
Healthcare funding 104
Major diseases of the developed world 105
Cardiovascular diseases 106
Cancer 106
Stress in developing nations 107
Acquired Immune Deficiency Syndrome (AIDS) 109
Malaria 111
Which technologies will succeed? 113
Illustrative cases 114
AIDS and malaria 115
Cardiovascular diseases 115
Cancer 116
Chapter 7 Wildcards for the future 125
Trends versus uncertainties 125
Wildcards 127
Society and politics 127
Public support of the biosciences? 127
A major pandemic? 129
Biotech rogue states? 130
Science and technology 131
Raging success or major meltdown? 131
Role of complementary industries? 132
Intellectual property regimes? 133
Qualified staff for healthcare and research? 133
Business and economics 134
Economic growth and global power shifts? 134
Venture capital and other funding sources? 135
Climate change and resource scarcity? 135
A scenario framework 136
The first overarching uncertainty: technological success 137
The second overarching uncertainty: societal acceptance 137
Multiple scenarios are possible 138
The role of stakeholders 141
Chapter 8 Scenarios up to 2025 143
Bio gridlock scenario 143
The view from 2025 143
How we got here 145
The world we live in 150
Analogous cases 151
Golden age scenario 153
The view from 2025 154
How we got here 154
The world we live in 158
Analogous case: information technology 160
Chapter 9 What it all means 163
You and your family 163
At work 168
Business and commerce 170
Society at large 172
Appendix A DNA, RNA, and protein 177
Molecules of inheritance 177
The structure of DNA 178
Cracking the code 179
Making proteins 180
Regulating gene expression 181
Appendix B Cloning genes 183
Restriction enzymes 183
Cloning procedure 184
Appendix C Complexity of the genome 187
Non-Coding RNAs 187
SNP variations 188
Glossary of Biomedical Terms 191
Acknowledgments 199
About the Authors 201
Index 203
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