Genes, Chromosomes, and Disease: From Simple Traits, to Complex Traits, to Personalized Medicine
- By Nicholas Wright Gillham
- Published Jun 9, 2011 by FT Press. Part of the FT Press Science series.
- Copyright 2011
- Dimensions: 6" x 9"
- Pages: 352
- Edition: 1st
- Book
- ISBN-10: 0-13-707544-8
- ISBN-13: 978-0-13-707544-7
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Product Author Bios
Nicholas Gillham (Pittsboro, NC) is professor emeritus of Biology and Genetics at Duke University, and a leading authority on organelle genetics. He is author of a textbook, Introduction to Microbiology (Macmillan, 1973), the monographs, Organelle Heredity (Raven Press, 1978) and Organelle Genes and Genomes (Oxford University Press, 1994), and a biography, A Life of Sir Francis Galton: From African Exploration to the Birth of Eugenics (Oxford University Press, 2001).
This very readable overview of the rise and transformations of medical genetics and of the eugenic impulses that have been inspired by the emerging understanding of the genetic basis of many diseases and disabilities is based on a popular nonmajors course, "Social Implications of Genetics," that Gillham gave for many years at Duke University. The book is suitable for use as a text in similar overview courses about genes and social issues or genes and disease. It gives a good overview of the developments and status of this field for a wide range of biomedical researchers, physicians, and students, especially those interested in the prospects for the new, genetics-based personalized medicine.
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13 of 14 people found the following review helpful
A World of Genetic Possibilities, By
This review is from: Genes, Chromosomes, and Disease: From Simple Traits, to Complex Traits, to Personalized Medicine (FT Press Science) (Hardcover)
Customer review from the Amazon Vine™ Program (What's this?)
Genes, Chromosomes, and Disease: From Simple Traits, to Complex Traits, to Personalized Medicine by Nicholas Wright Gillham provides a historical and current perspective in the field of genetic research. The book is well written and relatively easy to understand although the reader would benefit from having a rudimentary background in biology and genetics. Even without such a background Gillham has done a great job of providing enough clarity so that you can understand the main points postulated in the book without getting lost in the minutia.When reading Genes, Chromosomes, and Disease you get the sense of how complicated, wonderful and mysterious the human body is and how one mutation can result in a devastating disease or condition. Understanding how mutations that are referred to as single nucleotide polymorphisms (SNP's), along with the ability to classify them, can move genetic medicine toward the ability to literally provide "personalized medicine" for the patient... Read more
12 of 14 people found the following review helpful
Fascinating Look for the Layperson, By
This review is from: Genes, Chromosomes, and Disease: From Simple Traits, to Complex Traits, to Personalized Medicine (FT Press Science) (Hardcover)
Customer review from the Amazon Vine™ Program (What's this?)
This is a wonderful overview of the history of genetic research as it relates to disease, especially for individuals like myself who were humanities majors or not so scientifically inclined. There is a good bit of scientific jargon and the occasional table, but by and large this is a wholly accessibly text for anyone interested in the topic.In what is a relatively concise read, Professor Gillham details the ways in which geneticists hunt down disease genes, how diseases develop, and the interplay of risk factors that might lead to disease (susceptible genes, ethnicity, etc.). A particularly fascinating chapter deals with genes and behavior, and addresses issues such as bipolar disorder, alcoholism, and homosexuality. Gillham is not polemical, if that matters to you. He does not express an opinion on these matters either way, only reports on the history and current research taking place. There is also a chapter dedicated to preventing genetic diseases... Read more
4 of 5 people found the following review helpful
Epigenetics for geneticists, By
This review is from: Genes, Chromosomes, and Disease: From Simple Traits, to Complex Traits, to Personalized Medicine (FT Press Science) (Hardcover)
Customer review from the Amazon Vine™ Program (What's this?)
This is a very good book but not something I would pick up and read if you were a lay person interested in epigenetics. This is a book written for scientists or students of the genre. This is one of those books that is laden with scientific jargon and information and for the right crowd it is a great book. I think if you were interested in learning about this topic and you were not in the medical or research field this book might be a bit heavy for you.
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Online Sample Chapter
Table of Contents
Preface ix
Chapter 1: Hunting for disease genes 1
Chapter 2: How genetic diseases arise 25
Chapter 3: Ethnicity and genetic disease 55
Chapter 4: Susceptibility genes and risk factors 81
Chapter 5: Genes and cancer 103
Chapter 6: Genes and behavior 129
Chapter 7: Genes and IQ: an unfinished story 151
Chapter 8: Preventing genetic disease 175
Chapter 9: Treating genetic disease 199
Chapter 10: The dawn of personalized medicine 235
Postscript: a cautionary note 249
References and notes 253
Glossary 293
Some useful human genetics Web sites 307
Acknowledgments 309
About the author 311
Index 313
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